![]() Phosphate binders, including non-calcium-based phosphate binders and calcium-based phosphate binder, are widely used to lower serum phosphorus levels in CKD patients and prospective cohort study proved that treatment with phosphorus binders was independently associated with improved survival among incident hemodialysis patients. A growing body of evidence proved the correlation between elevated serum phosphorus, PTH and calcium in CKD patients, and increased morbidity, mortality, hospitalization rate, cost of care, as well as reduced quality of life. Serum phosphorus in chronic kidney disease (CKD) patients accumulates with the decrease of glomerular filtration rate (GFR), which cause secondary elevation of parathyroid hormone (PTH) level and consequently reduces calcitriol concentration by inhibiting its secretion and promoting its metabolism. The funders of this research had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. 12DJ1400300) and Key Projects in the National Science & Technology Pillar Program in the Twelfth Five-year Plan Period (No. 13030340419), Major Fundamental Research Program of Shanghai Committee of Science and Technology (No. ![]() This work was supported by Chinese Society of Nephrology (No. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedĭata Availability: All relevant data are within the paper and its Supporting Information files.įunding: Zhiguo Mao is an Outstanding Young Scholar of Second Military Medical University. ![]() Received: AugAccepted: JanuPublished: March 23, 2015Ĭopyright: © 2015 Wang et al. PLoS ONE 10(3):Īcademic Editor: Pasqual Barretti, Sao Paulo State University, BRAZIL ![]() Citation: Wang Y, Xie G, Huang Y, Zhang H, Yang B, Mao Z (2015) Calcium Acetate or Calcium Carbonate for Hyperphosphatemia of Hemodialysis Patients: A Meta-Analysis. ![]()
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